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The PS framework has become more known in drug development since its inclusion as one of the five strategies for handling intercurrent events in the estimand framework (ICH E9(R1) guideline 2020) and the availability of programming macros
The pooled analyses of placebo-controlled studies in children and adolescents with MDD, Obsessive Compulsive Disorder (OCD), or other psychiatric disorders included a total of 24 short-term studies of 9 antidepressant drugs in over 4,400 patients
Yes, interactions with medications like antidepressants, stimulants, or other diabetes drugs can potentially contribute to mood changes
Cell Mol Biol Lett
A similar study of lorcaserin yielded a neutral result
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